Accessed July 11, Whelton PK, et al. Wright JM, et al. First-line drugs for hypertension. Cochrane Database of Systematic Reviews. Accessed July 18, Aronson JK, ed. Alpha-adrenoceptor antagonists.
In: Meyler's Side Effects of Drugs. Amsterdam, Netherlands: Elsevier; Alpha-1 adrenergic blockers. Facts and Comparisons eAnswers.
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Similarities — Alpha vs Beta Blockers 5. Alpha vs Beta Blockers in Tabular Form 6. Summary — Alpha vs Beta Blockers. Alpha blockers are drugs that lower blood pressure by preventing the hormone norepinephrine from tightening the smooth muscles in the walls of arteries and veins.
Norepinephrine is the agonist for these receptors. These receptors have a common function, such as vasoconstriction. Therefore, alpha blockers prevent such functions upon binding to the receptor. As a result of alpha blockers binding to their receptors, the blood vessels remain open and relaxed. This improves blood flow and reduces blood pressure. Both beta-blockers and alpha-blockers are never prescribed as a first-line treatment for blood pressure. Meaning both beta and alpha-blockers are not a single medication treatment for blood pressure.
In short, Beta-blockers block the beta 1 and beta 2 receptors, whereas alpha-blockers block the alpha-adrenergic receptors.
Beta-blockers block the beta 1 heart and beta 2 lung receptors from stimulating or exerting their effects. Blocking the receptors affects the hormone epinephrine, also known as adrenaline, which is released as a result of the stimulated receptors.
The blocking effect either prevents or limits stimulation and enables your heart to beat slower and with less force, reducing blood pressure. Apart from this, blocking beta 1 and beta 2 receptors helps open up your veins and arteries in the heart, improving blood flow and reducing the inbuilt pressure. Not only that, but beta-blockers also support your kidneys to block a hormone called angiotensin II, which also lowers blood pressure.
The ends of some nerves release a chemical called noradrenaline norepinephrine when the nerves are stimulated. This causes the nerves to, in turn, stimulate alpha-adrenergic receptors. These receptors are a tiny structure that appear in different parts of the body. Check out our online video lectures and start your pharmacology course now for free!
Bladder In contrast to receptors, these stimulate bladder relaxation No effect on ejaculation Bronchioles Bronchiolar smooth muscle relaxation Kidney Increase the renin secretion Liver Increased glycogenolysis.
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